More interesting discoveries from the RV144 trial (Tweeted by @TweetSosa )
A recent paper by a multi-center group looking into the famous "31.2% vaccine efficacy" study (RV144 trial) shows interesting features associated with this protection against HIV-1.
Shuying Li looked at vaccine-induced Fc receptor-mediated antibody function and in this paper, show that a single nucleotide polymorphism in the FcR-encoding genes is strongly associated with protection. Individuals with a SNP (rs114945036) carrying CC in this SNP had a vaccine efficacy of 15% while those with a CT or TT had a vaccine efficacy of 91% against HIV-1 subtype CRF01_AE with a lysine at position 169 (169K) in the V2 loop.
RV144 is a treasure trove of discoveries.
The world is eagerly waiting for more data and a cure!
This has been tweeted:
Shuying Li looked at vaccine-induced Fc receptor-mediated antibody function and in this paper, show that a single nucleotide polymorphism in the FcR-encoding genes is strongly associated with protection. Individuals with a SNP (rs114945036) carrying CC in this SNP had a vaccine efficacy of 15% while those with a CT or TT had a vaccine efficacy of 91% against HIV-1 subtype CRF01_AE with a lysine at position 169 (169K) in the V2 loop.
RV144 is a treasure trove of discoveries.
The world is eagerly waiting for more data and a cure!
This has been tweeted:
In Study of HIV Vaccine Trial Subjects, Genotype Defines Subsets with Strong and Weak Response http://dlvr.it/6gQWts
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